Lung hyperinflation in COPD: applying physiology to clinical practice

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Lung hyperinflation in COPD: applying physiology to clinical practice

In chronic obstructive pulmonary disease (COPD), worsening expiratory flow limitation together with alteration in the elastic properties of the lung are associated with progressive lung hyperinflation and gradual decline in the resting inspiratory capacity over time. Dynamic hyperinflation (DH) refers to the variable increase in end-expiratory lung volume (EELV) above the relaxation volume (VR)...

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Physiology and consequences of lung hyperinflation in COPD

Lung hyperinflation commonly accompanies expiratory flow limitation in patients with chronic obstructive pulmonary disease (COPD) and contributes importantly to morbidity and an impoverished quality of life. It is not surprising, therefore, that lung hyperinflation has become an important therapeutic target in symptomatic COPD patients. Acute dynamic increases in lung hyperinflation under condi...

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Longitudinal changes in lung hyperinflation in COPD

PURPOSE COPD is characterized by an accelerated and progressive decline in forced expiratory volume in 1 second (FEV1) and lung hyperinflation. Although lung hyperinflation is the hallmark of COPD, data on the longitudinal changes in lung hyperinflation and any association with the decline in FEV1 are lacking. The aim of this study was to evaluate the longitudinal changes in lung hyperinflation...

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LUNG HYPERINFLATION IN COPD: What the Clinician Needs to Know

Lung hyperinflation, chronic dyspnea and reduced exercise capacity are inextricably linked and are independent predictors of increased mortality in COPD. It is no surprise, therefore, that a major goal of management is to reduce lung hyperinflation in the hope of improving dyspnea, exercise tolerance and related long term patientcentered outcomes. The negative effects of lung hyperinflation on ...

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CPAP decreases lung hyperinflation in patients with stable COPD.

BACKGROUND Dynamic hyperinflation, caused by expiratory flow limitation, markedly increases resting end-expiratory lung volume (functional residual capacity) in many COPD patients. OBJECTIVE To determine the impact and duration of impact of CPAP on hyperinflation and airway resistance in patients with stable COPD. METHODS In a case series, 21 patients underwent CPAP at 8 cm H(2)O for 15 min...

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ژورنال

عنوان ژورنال: COPD Research and Practice

سال: 2015

ISSN: 2054-9040

DOI: 10.1186/s40749-015-0008-8